Publications

abstract_rjp2.tif

Fanourakis, A.; Williams, B. D.; Paterson, K. J.; Phipps, R. J. Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation J. Am. Chem. Soc., 2021 143, 10070–10076

abs1.jpg

Gillespie, J. E.; Morrill, C.; Phipps, R. J. Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines J. Am. Chem. Soc., 2021, 143, 9355–9360

abs3.tif

Proctor, R. S. J.; Chuentragool, P.; Colgan, A. C.; Phipps, R. J. Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides J. Am. Chem. Soc., 2021, 143, 4928-4934

absjpg.jpg
TOCjpg.jpg

Ermanis, K.;* Colgan, A. C.; Proctor, R. S. J. ; Hadrys, B. W.; Phipps, R. J.;* Goodman, J. M.* A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction. J. Am. Chem. Soc. 2020,142, 21091–21101.

Feature article in Trends in Chemistry (Mechanism of the Month feature):

Colgan, A. C.; Phipps, R. J. Catalytic Enantioselective Minisci Reaction, Trends Chem. 2020 In Press

tocjpg.jpg

Proctor, R. S. J.; Colgan, A. C.; Phipps, R. J. Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates, Nature Chemistry, 2020, 12, 990-1004.

Graphical_Abstract_UPDATED.jpg

Fanourakis, A.; Docherty, P.J.; Chuentragool, P.; Phipps, R.J. Recent Developments in Enantioselective Transition Metal Catalysis Featuring Attractive Noncovalent Interactions between Ligand and Substrate, ACS Catalysis, 2020, 10, 10672-10714

nrn02345sf.001.gif

Genov, G. R.; Douthwaite, J. L.; Phipps, R. J.  5′‐Methyl[2,2′‐bipyridine]‐5‐methanesulfonic Acid, Tetrabutylammonium Salt eEROS, Encyclopedia of Reagents for Organic Synthesis, Wiley, 2020

Basia toc.gif

Hadryš, B.; Phipps, R. J. Acid and Solvent Effects on the Regioselectivity of Minisci-Type Addition to Quinolines Using Amino Acid Derived Redox Active Esters Synlett, 2020, just accepted. Invited contribution to Cluster on Heterocyclic Chemistry.

graphicalbstract_mod.png

Genov, G. R.^; Douthwaite, J. L.^; Lahdenperä, A.S.K.; Gibson, D. C.; Phipps, R. J.  Enantioselective remote C–H activation directed by a chiral cation Science, 2020, 367, 1246-1251

(^Equal contribution)

Highlighted in:   Synfact of the Month "Chiral Cation–Anion Ligand Pair Directs Highly Selective Remote C–H Activation"

                         

Screenshot%202020-02-19%20at%2013.57_edi
abstract_minisci2.jpg

Reid, J. P.^; Proctor, R. S. J.^; Sigman, M. S.*; Phipps, R. J.* Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

J. Am. Chem. Soc. 2019, 141, 19178-19185

(^Equal Contribution)

abstract.jpg

Mihai, M. T.; Williams, B. D.; Phipps, R. J. Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation J. Am. Chem. Soc. 2019, 141, 15477-15482

Highlighted in: Chemistry World "Steric shield leads boron to aromatic rings’ most remote region"

Screen Shot 2019-05-24 at 19.12.07.png
Dark side of the moon2.png

Proctor, R. S. J.; Phipps, R. J. Recent Advances in Minisci-Type Reactions  Angew. Chem. Int. Ed. 2019 58, 13666-13699

abstract.jpg

Golding, W. A.; Pearce-Higgins, R.; Phipps, R. J. Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically-Directed Palladium Catalysis J. Am. Chem. Soc. 2018, 140, 13570–13574.

Minisci Toc.jpeg

Proctor, R. S. J.; Davis, H. J.; Phipps, R. J. Catalytic enantioselective Minisci type addition to heterorenes Science 2018360, 419-422 .

Highlighted in:   C&E News "Radical new way to control chirality"

                            Chemistry World "Making light work of synthesis"

Proof - TOC modified.jpg
Get.jpeg
20.jpg
angewandte TOC.png

Davis, H. J.; Genov, G. R.; Phipps, R. J. Meta Selective C-H Borylation of Benzylamine, Phenethylamine and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand Angew. Chem. Int. Ed201756, 13351-13355.

Get-2.jpeg

Montenegro, J.; Phipps, R. J.; Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017 Chem. Commun. 201753, 9960-9966.

19.jpg
ga.jpg
JACS TOC.gif

Davis, H. J.; Mihai, M. T.; Phipps, R. J.; Ion Pair-Directed Regiocontrol in Transition Metal Catalysis: A Meta-Selective C–H Borylation of Aromatic Quaternary Ammonium Salts J. Am. Chem. Soc. 2016138, 12759-12762.

 

Post-Doc

15.

14.

13.

12.

Yang, X.*; Phipps, R. J.*; Toste, F. D. Asymmetric Fluorination of a-Branched Cyclohexanones Enabled by a Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014136, 5225-5528 *(Authors contributed equally).

11.

Wu, J.; Wang, Y.; Drljevic, A.; Rauniyar,V.; Phipps, R. J.; Toste, F. D. A combination of directing groups and chiral anion phase-transfer catalysis for enantioselective fluorination of alkenes. Proc. Natl. Acad. Sci. USA 2013110, 13729-13733

10.

9.

Honjo, T.; Phipps, R. J.; Rauniyar, V.; Toste, F. D. A doubly axially chiral phosphoric acid catalyst for the asymmetric tandem oxyfluorination of enamides. Angew. Chem. Int. Ed. 201251, 9684-9688.

8.

Phipps, R. J.; Hamilton, G. L.; Toste, F. D. The progression of chiral anions from concepts to applications in asymmetric catalysis. Nature Chem. 20124, 603-614.

7.

Phipps, R. J.; Hiramatsu, K.; Toste, F. D. Asymmetric fluorination of enamides: access to a-fluoroimines using an anionic chiral phase-transfer catalyst J. Am. Chem. Soc. 2012134, 8376-8379.

 

PhD

6.

Phipps, R. J.; McMurray, L. M.; Duong, H. A.; Ritter, S.; Gaunt, M. J. Copper-catalyzed alkene arylation with diaryliodonium salts. J. Am. Chem. Soc2012134, 10773-10776.

5.

Duong, H. A.; Gilligan, R. E.; Cooke, M. L.; Phipps, R. J.; Gaunt, M. J. Copper(II)-catalyzed meta-selective direct arylation of a-aryl carbonyl compounds. Angew. Chem. Int. Ed. 201150, 463-466.

4.

Ciana, C. L.; Phipps, R. J.; Brandt, J. R.; Magnus, F. –M.; Gaunt, M. J.  A highly para-selective copper(II)-catalyzed direct arylation of aniline and phenol derivatives. Angew. Chem. Int. Ed. 201150, 458-462.

3.

Phipps, R. J.; Gaunt, M. J. A meta-selective copper-catalyzed C-H bond arylation. Science 2009, 323, 1593-1597.

2.

Phipps, R. J.; Grimster, N. P.; Gaunt, M. J. Cu(II)-catalyzed direct and site-selective arylation of indoles under mild conditions. J. Am. Chem. Soc. 2008130, 8172-8174.

 

Undergraduate

1.

Paddock, V.L.; Phipps, R. J.; Conde-Angulo, A.; Blanco-Martin, A.; Giró-Mañas, C.; Martin, L. J.; White, A. J. P.; Spivey, A. C. (±)-trans,cis-4-Hydroxy-5,6-di-O-isopropylidenecyclohex-2-ene-1-one: synthesis and facile dimerization to decahydrodibenzofurans.  J. Org. Chem. 201176, 1483-1486.