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Paterson, K. J.; Dahiya, A.; Williams, B. D.; Phipps, R. J. Tertiary Amides as Directing Groups for Enantioselective C-H Amination using Ion-Paired Rhodium Complexes Angew. Chem. Int. Ed. 2024, Accepted Article 


Docherty, P. J.; Kadarauch, M.; Mistry, N.; Phipps, R. J. Application of sSPhos as a Chiral Ligand for Palladium-Catalyzed Asymmetric Allylic Alkylation Org. Lett. 2024, ASAP Article (Contribution to  Organic Chemistry Driven by Academic-Industrial Collaborations special issue)


Kadarauch, M.; Whalley, D. M.; Phipps, R. J. sSPhos: A General Ligand for Enantioselective Arylative Phenol Dearomatization via Electrostatically-Directed Palladium Catalysis J. Am. Chem. Soc. 2023, 145, 25553–25558.


Ermanis, K.*; Gibson, D. C.; Genov, G. R.; Phipps, R. J.* Interrogating the Crucial Interactions at Play in the Chiral Cation-Directed Enantioselective Borylation of Arenes ACS Catal. 2023, 13, 13043-13055


Gillespie, J. E.; Lam, N. Y. S.; Phipps, R. J. Ortho-Selective Amination of Arene Carboxylic Acids via Rearrangement of Acyl O-Hydroxylamines Chem. Sci. 2023 14, 10103-10111


Bacoș, P. D.^; Lahdenperӓ, A. S. K.^; Phipps, R. J Discovery and Development of the Enantioselective Minisci Reaction Acc. Chem. Res. 2023, 56, 2037-2049  (^ Equal contribution)


Fanourakis, A.; Hodson, N.; Lit, A. R. and Phipps, R. J. Substrate-Directed Enantioselective Aziridination of Alkenyl Alcohols Controlled by a Chiral Cation J. Am. Chem. Soc. 2023, 145, 7516–7527


Lahdenperӓ, A. S. K.; Bacoș, P. D.; Phipps, R. J. Enantioselective Giese Additions of Prochiral α-Amino Radicals J. Am. Chem. Soc. 2022, 144,  22451-22457.


Gillespie, J. E.;^ Fanourakis, A. F.;^ Phipps, R. J. Strategies That Utilize Ion Pairing Interactions to Exert Selectivity Control in the Functionalization of C–H Bonds J. Am. Chem. Soc., 2022, 144, 18195-18211 (^ Equal contribution)


Pearce-Higgins, R.;^ Hogenhout, L. N.; ^ Docherty, P. J.; ^ Whalley, D.M.; Chuentragool, P.; Lee, N.; Lam, N. Y. S.; McGuire, T.M.; Valette, D.; Phipps, R. J. An Enantioselective Suzuki-Miyaura Coupling to Form Axially Chiral Biphenols J. Am. Chem. Soc., 2022144, 15026-15032

(^ Equal contribution)


Morrill, C.; Gillespie, J. E.; Phipps, R. J. An Aminative Rearrangement of O-(Arenesulfonyl)hydroxylamines: Facile Access to ortho-Sulfonyl Anilines Angew. Chem. Int. Ed. 2022, 61, e202204025


Douthwaite, J. L.; Phipps, R. J. Extended Sulfonated Bipyridine Ligands Targeting the Para-Selective Borylation of Arenes Tetrahedron, 2022, 117, 132831

(Invited contribution for special issue in honour of Professor Franziska Schoenebeck on her receipt of the 2022 Tetrahedron Young Investigator Award.)


Colgan, A. C.; Proctor, R. S. J.; Gibson, D. C.; Chuentragool, P.; Lahdenperӓ, A. S. K.; Ermanis, K.;* Phipps, R. J.* Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols Angew. Chem. Int. Ed., 2022, 61, e202200266


Fanourakis, A.; Williams, B. D.; Paterson, K. J.; Phipps, R. J. Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation J. Am. Chem. Soc., 2021 143, 10070–10076


Gillespie, J. E.; Morrill, C.; Phipps, R. J. Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines J. Am. Chem. Soc., 2021, 143, 9355–9360


Proctor, R. S. J.; Chuentragool, P.; Colgan, A. C.; Phipps, R. J. Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides J. Am. Chem. Soc., 2021, 143, 4928-4934


Ermanis, K.;* Colgan, A. C.; Proctor, R. S. J. ; Hadrys, B. W.; Phipps, R. J.;* Goodman, J. M.* A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction. J. Am. Chem. Soc. 2020,142, 21091–21101.

Feature article in Trends in Chemistry (Mechanism of the Month feature):

Colgan, A. C.; Phipps, R. J. Catalytic Enantioselective Minisci Reaction, Trends Chem. 2020 In Press


Proctor, R. S. J.; Colgan, A. C.; Phipps, R. J. Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates, Nature Chemistry, 2020, 12, 990-1004.


Fanourakis, A.; Docherty, P.J.; Chuentragool, P.; Phipps, R.J. Recent Developments in Enantioselective Transition Metal Catalysis Featuring Attractive Noncovalent Interactions between Ligand and Substrate, ACS Catalysis, 2020, 10, 10672-10714


Genov, G. R.; Douthwaite, J. L.; Phipps, R. J.  5′‐Methyl[2,2′‐bipyridine]‐5‐methanesulfonic Acid, Tetrabutylammonium Salt eEROS, Encyclopedia of Reagents for Organic Synthesis, Wiley, 2020

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Hadryš, B.; Phipps, R. J. Acid and Solvent Effects on the Regioselectivity of Minisci-Type Addition to Quinolines Using Amino Acid Derived Redox Active Esters Synlett, 2020, just accepted. Invited contribution to Cluster on Heterocyclic Chemistry.


Genov, G. R.^; Douthwaite, J. L.^; Lahdenperä, A.S.K.; Gibson, D. C.; Phipps, R. J.  Enantioselective remote C–H activation directed by a chiral cation Science, 2020, 367, 1246-1251

(^Equal contribution)

Highlighted in:   Synfact of the Month "Chiral Cation–Anion Ligand Pair Directs Highly Selective Remote C–H Activation"



Reid, J. P.^; Proctor, R. S. J.^; Sigman, M. S.*; Phipps, R. J.* Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

J. Am. Chem. Soc. 2019, 141, 19178-19185

(^Equal Contribution)


Mihai, M. T.; Williams, B. D.; Phipps, R. J. Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation J. Am. Chem. Soc. 2019, 141, 15477-15482

Highlighted in: Chemistry World "Steric shield leads boron to aromatic rings’ most remote region"

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Proctor, R. S. J.; Phipps, R. J. Recent Advances in Minisci-Type Reactions  Angew. Chem. Int. Ed. 2019 58, 13666-13699


Golding, W. A.; Pearce-Higgins, R.; Phipps, R. J. Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically-Directed Palladium Catalysis J. Am. Chem. Soc. 2018, 140, 13570–13574.

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Proctor, R. S. J.; Davis, H. J.; Phipps, R. J. Catalytic enantioselective Minisci type addition to heterorenes Science 2018360, 419-422 .

Highlighted in:   C&E News "Radical new way to control chirality"

                            Chemistry World "Making light work of synthesis"

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Davis, H. J.; Genov, G. R.; Phipps, R. J. Meta Selective C-H Borylation of Benzylamine, Phenethylamine and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand Angew. Chem. Int. Ed201756, 13351-13355.


Montenegro, J.; Phipps, R. J.; Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017 Chem. Commun. 201753, 9960-9966.


Davis, H. J.; Mihai, M. T.; Phipps, R. J.; Ion Pair-Directed Regiocontrol in Transition Metal Catalysis: A Meta-Selective C–H Borylation of Aromatic Quaternary Ammonium Salts J. Am. Chem. Soc. 2016138, 12759-12762.






Yang, X.*; Phipps, R. J.*; Toste, F. D. Asymmetric Fluorination of a-Branched Cyclohexanones Enabled by a Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014136, 5225-5528 *(Authors contributed equally).


Wu, J.; Wang, Y.; Drljevic, A.; Rauniyar,V.; Phipps, R. J.; Toste, F. D. A combination of directing groups and chiral anion phase-transfer catalysis for enantioselective fluorination of alkenes. Proc. Natl. Acad. Sci. USA 2013110, 13729-13733



Honjo, T.; Phipps, R. J.; Rauniyar, V.; Toste, F. D. A doubly axially chiral phosphoric acid catalyst for the asymmetric tandem oxyfluorination of enamides. Angew. Chem. Int. Ed. 201251, 9684-9688.


Phipps, R. J.; Hamilton, G. L.; Toste, F. D. The progression of chiral anions from concepts to applications in asymmetric catalysis. Nature Chem. 20124, 603-614.


Phipps, R. J.; Hiramatsu, K.; Toste, F. D. Asymmetric fluorination of enamides: access to a-fluoroimines using an anionic chiral phase-transfer catalyst J. Am. Chem. Soc. 2012134, 8376-8379.



Phipps, R. J.; McMurray, L. M.; Duong, H. A.; Ritter, S.; Gaunt, M. J. Copper-catalyzed alkene arylation with diaryliodonium salts. J. Am. Chem. Soc2012134, 10773-10776.


Duong, H. A.; Gilligan, R. E.; Cooke, M. L.; Phipps, R. J.; Gaunt, M. J. Copper(II)-catalyzed meta-selective direct arylation of a-aryl carbonyl compounds. Angew. Chem. Int. Ed. 201150, 463-466.


Ciana, C. L.; Phipps, R. J.; Brandt, J. R.; Magnus, F. –M.; Gaunt, M. J.  A highly para-selective copper(II)-catalyzed direct arylation of aniline and phenol derivatives. Angew. Chem. Int. Ed. 201150, 458-462.


Phipps, R. J.; Gaunt, M. J. A meta-selective copper-catalyzed C-H bond arylation. Science 2009, 323, 1593-1597.


Phipps, R. J.; Grimster, N. P.; Gaunt, M. J. Cu(II)-catalyzed direct and site-selective arylation of indoles under mild conditions. J. Am. Chem. Soc. 2008130, 8172-8174.



Paddock, V.L.; Phipps, R. J.; Conde-Angulo, A.; Blanco-Martin, A.; Giró-Mañas, C.; Martin, L. J.; White, A. J. P.; Spivey, A. C. (±)-trans,cis-4-Hydroxy-5,6-di-O-isopropylidenecyclohex-2-ene-1-one: synthesis and facile dimerization to decahydrodibenzofurans.  J. Org. Chem. 201176, 1483-1486.

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